Perinatology

10 wks

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Avera McKennan – Les Heddleston

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Genetic Diseases: Are there treatments available before birth?

Discussion of whether before birth treatment is an option. Presented by Brian Shaffer MD, Assistant Clinical Professor, UCSF Reproductive Genetics & Perinatology.

精子“品質~~~影響~~~~胚胎品質

精子品質影響胚胎品質1 2 7 9 10 4 Developmental sperm contributions: fertilization and beyond Developmental sperm contributions: fertilization and beyond Gerardo Barroso, MD, M.Sc.,a Carlos Valdespin, MD,a Eva Vega, M.Sc.,a Ruben Kershenovich, MD,a Rosaura Avila, B.Sc.,a Conrado Avenda~no, MD,b and Sergio Oehninger, MD, Ph.Db a Reproductive Medicine and Infertility Division, National Institute of Perinatology, Mexico City, Mexico; and b Obstetrics and Gynecology Department, Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia The objective of this review was to examine the role of the various spermatozoal components suspected of actively participating in early human development. The contributions of the fertilizing spermatozoon to the oocyte include, as a minimum, the delivery of the DNA/chromatin, a putative oocyte-activating factor (OAF), and a centriole. Recent data indicate that spermatozoa may also provide the zygote with a unique suite of paternal mRNAs; some transcripts might be crucial for early and late embryonic development and deficient delivery, or aberrant transcription might contribute to abnormal development and arrest. Clinical evidence from assisted reproduction suggests that failure to complete the fertilization process, syngamy, or early cleavage might be the result of an early paternal effect. It is speculated that an abnormal release of a putative OAF and/or dysfunctions of the centrosome and cytoskeletal …

Book reviews 1: Medical Fallacies & Ethical dilemmas

Just wanted to recommend a couple of books I have read recently: 1. Follies & Fallacies In Medicine by Petr Skrabanek & James McCormick ISBN 1 870781 02 3 (Note this edition is from 1989 – newer editions have been published) 2. Matters of Life & Death by John Wyatt ISBN 9 781844 743674

Genetic Diseases: Diagnosis Before Birth

Description of the types of Genetic Diseases that can be treated before birth. Presented by Brian Shaffer MD, Assistant Clinical Professor, UCSF Reproductive Genetics & Perinatology.

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